RNA Accelerator Postdoctoral Research Fellow, Cancer Immunology Discovery

Pfizer Inc.

La Jolla, CA

Job posting number: #7115543 (Ref:pf-4860600)

Posted: November 7, 2022

Application Deadline: Open Until Filled

Job Description

ROLE SUMMARY

The Cancer Immunology Discovery group at Pfizer is seeking an ambitious Post-Doctoral Research Scientist with strong research and communication skills to undertake a highly visible research project shared between the CID and BioMedicine Design groups.  The successful candidate will aim to leverage mRNA lipid nanoparticle (mRNA-LNP) technology to enhance T cell activity against tumors.  This work will depend heavily on the candidate’s ability to derive novel in vitro/in vivo experimental models and complete related experiments to give an early glimpse at the clinical potential of this approach.

ROLE RESPONSIBILITIES

We are seeking a self-starting, highly motivated, and technically proficient scientist with a PhD in Immunology or Cancer Biology to apply a variety of cutting-edge tools including molecular, cellular, and biochemical techniques alongside immunofluorescence imaging, high parameter flow cytometry, and bioinformatics in preclinical in vivo models to address key questions within the scope of the proposed work. (S)he will work in a fast-paced and highly collaborative research environment and will be expected to present their findings in high-impact journals and at internal and external scientific conferences.

QUALIFICATIONS

BASIC QUALIFICATIONS

  • PhD degree with experience in Immunology, Tumor biology, Oncology, or related discipline.
  • A high-level understanding of key concepts in cancer immunology
  • A strong desire to learn, it is not expected that the successful candidate will have experience with all required techniques; however, they must be willing to expand their technical and scientific capabilities
  • Expertise in multiparameter flow cytometry, transcriptional analyses, ex vivo mouse tissue processing, in vivo syngeneic/GEM tumor models
  • Experience in mouse handling and primary cell tissue harvest
  • Expertise in mouse and human tumor cell culture

PREFERRED QUALIFICATIONS

  • Scientific and technical knowledge of mRNA-LNP technology
  • Significant molecular biology experience including CRISPR-mediated deletion of genes and overexpression of model antigens in mouse syngeneic tumor cell lines
  • Expertise in bulk and single cell RNA-Seq, ELISA, and Western blot experimentation and analyses

  

OTHER JOB DETAILS

Eligible for ​Relocation Assistance

Must Have Work Authorization in US

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Research and Development



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


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More Info

Job posting number:#7115543 (Ref:pf-4860600)
Application Deadline:Open Until Filled
Employer Location:Pfizer Inc.
New York,New York
United States
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